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Joint Bayesian Semiparametric Regression Analysis of Recurrent Adverse Events and Survival

Juhee Lee, Ph.D., Assistant Professor, Applied Mathematics and Statistics, UC Santa Cruz

Tuesday, February 7, 2017
  3:45–4:45 p.m.

Location: Olmsted Hall 420
  Parking Information

Category: Colloquium


Juhee Lee, Ph.D.
Assistant Professor
Department of Applied Mathematics and Statistics
University of California Santa Cruz

Joint Bayesian Semiparametric Regression Analysis of Recurrent Adverse Events and Survival

We propose a Bayesian semiparametric joint regression model for a recurrent event process and survival time. Assuming independent latent subject frailties, marginal models for each subject are defined for the recurrent event process and survival distribution as functions of the subject’s frailty and covariates. Averaging over the frailty distribution yields a joint model. A robust Bayesian model is obtained by assuming a Dirichlet process for the frailty distribution. The model is applied to analyze an observational dataset from esophageal cancer patients treated with radiation therapy, including recurrent effusions of fluid to the heart or lungs. A simulation study is presented that compares posterior estimates under the joint model to simpler Bayesian models that ignore either the recurrent event process or survival time, and also to a frequentist joint model. The simulations show that the proposed Bayesian joint model does a good job of correcting for treatment assignment bias, is robust to a mild violation of the frailty model assumption, and has favorable estimation reliability and accuracy compared with each of the Bayesian sub-models and the frequentist joint model.

Dr. Lee earned her Ph.D. in Statistics in 2010 and her M.S. in Statistics in 2006 from The Ohio State University. She also earned her B.S. in Statistics with a Minor in Computer Science and Engineering, from Ewha Woman’s University, Seoul, Korea in 1999. She was a Visiting Assistant Professor, in the Department of Statistics, at The Ohio State University from August 2012-August 2013. She was a Postdoctoral Fellow in Biostatistics, from June 2010-August 2012 at the University of Texas, M.D. Anderson Cancer Center in Houston, TX.


Additional Information:

Open to: General Public
Admission: Free
Sponsor: Statistics Department

Contact Information:
Paula Lemire
(951) 827-6009