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Combined multi-scale computational and experimental study of the impacts of cell properties on mitotic cell rounding in developing epithelia

Mark Alber | Distinguished Professor of the Department of Mathematics, University of California, Riverside

Wednesday, February 1, 2017
  11:10 a.m.–Noon

Location: Chung Hall 205/206
  Parking Information

Category: Colloquium

Description: MR has been studied extensively in individual cultured cells, but the physical mechanisms regulating MR in intact tissues are still poorly understood. Whether these changes are purely additive, synergistic or impact separate aspects of MR is not clear. Specific modulation of these processes in dividing cells within a tissue is experimentally challenging, because of off-target effects and the difficulty of targeting only dividing cells. General computational models for investigating in detail epithelial mechanotransduction, especially MR, require biologically calibrated submodels capable of representing non polygonal cell shapes, and simulating the membranes as well as cytoplasm of individual cells as separate entities. To accomplish this, a novel multi-scale sub-cellular model, called Epi-scale, was developed for simulating mechanical properties of cells in the developing columnar epithelium of the wing disc which consists of a single layer of cells.

Additional Information: To read more, click here.

Open to: General Public
Admission: Free
Sponsor: Bioengineering Department

Contact Information:
Nancy Ford
(951) 827-5025