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Interdisciplinary Seminar on Mathematical & Computational Modeling: "Computational Modeling of Protein Dynamics and Interactions"

Dr. Dimitrios Morikis, Department of Bioengineering, UC Riverside

Monday, March 20, 2017
  12:10–1:10 p.m.


Location: Surge Building 268
  Parking Information

Category: Seminar

Description:

We will present our recent work on the dynamics of protein-protein interactions at different scales. The common theme in our presentation is modeling of components of the immune system. First, we will discuss our ODE system that describes biochemical reactions of the activation pathways of the complement system, a component of the innate immune system and a link between innate and adaptive immunity. Second, we will discuss our computational framework AESOP for the analysis of Poisson-Boltzmann electrostatic potentials to determine the role of electrostatics in protein-protein recognition and binding for families of related proteins. Third, we will discuss the analysis of microsecond molecular dynamics simulations of a chemokine receptor in its free and ligand-bound states to delineate functional local and global conformational transitions in response to biased ligand binding. We will discuss applications in modeling disease states and personalized medicine, and in protein design and drug discovery.



Additional Information: ISMCM

Open to: General Public
Admission: Free
Sponsor: Mathematics

Contact Information:
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