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Interdisciplinary Seminar: "Combined modeling and experimental study of fibrin networks"

Oleg Kim, UC Riverside Mathematics

Monday, April 24, 2017
  12:10–1:10 p.m.

Location: Surge Building 268
  Parking Information

Category: Seminar


Fibrin network is a major structural component of protective hemostatic clots and pathological obstructive thrombi that largely determines their mechanical stability in response to external loads including shear and compressive forces. In particular, fibrin networks reveal a unique nonlinear mechanical behavior characterized by a dual softening-stiffening transition as the networks are exposed to compressive loads, with softening occurring at small and intermediate compressive strains, while hardening developing at larger degrees of compression. Using a combination of confocal microscopy and rheological measurements, we demonstrate that these non-linear mechanical properties originated from structural rearrangements of the entire fibrin network, as well as alterations of individual fibers including fiber buckling, bending and reorientation. The network hardening strongly correlates with an increase in the number of intersecting fibers, resulting from densification of the compressed network and reorientation of the whole fibrillar network toward a planar structural architecture perpendicular to the direction of negative strain.We model this nonlinear behavior using a continuum theory of phase transitions and analytically predicted the storage and loss moduli which were in good agreement with the experimental data. We also demonstrate that permeability of the fibrin network and protein diffusivity are important factors determining the transport of blood proteins inside the thrombus.

Additional Information: ISMCM

Open to: General Public
Admission: Free
Sponsor: Mathematics

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