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Interdisciplinary Seminar on Mathematical & Computational Modeling: "Impact of Mechanical Stability and Permeability of a Blood Clot on Embolization"

Dr. Shixin Xu Department of Mathematics. UC Riverside

Monday, May 1, 2017
  12:10–1:10 p.m.


Location: Surge Building 268
  Parking Information

Category: Seminar

Description:

Thromboembolism, one of the leading causes of death and disability worldwide, is characterized by formation of intravascular clots (thrombi) formed in response to vascular injury which are dynamic multicomponent structures strongly influenced by the blood shear. To study the interplay of flow-induced deformations of a clot, platelet adhesion and peeling, clot permeability and mechanical stability, a novel multi-scale multiphase computational model was developed describing interactions between fibrin, highly and partially activated platelets, red blood cells, and liquid plasma. Based on the experimental evidence clot is assumed in model simulations to consist of a core made of fibrin and highly activated platelets and a shell composed of partially activated platelets, surrounded by continuously flowing blood. Simulation results show that flow-dependent deformability of the entire clot is determined by the two shear-dependent mechanisms. First macroscale mechanism of the clot volume reduction is based on tearing off of clot fragments. Second microscale mechanism is based on the influx and removal of platelets from the shell. Based on these mechanisms, model simulations allowed to predict the size and structure of a small non-occluding arterial blood clot as it stabilizes for various flow shear rates. The model also predicts that permeability of the shell region strongly affects the mechanical stability of the blood clot, such that increase in clot permeability leads to embolization, while a low permeability clots were more resistant to deformation. Lastly, simulations of arterial clot deformation dynamics reveal that incoroporation of reds blood cells (RBCs) into a clot  can reduce the average deformability of the clot by as much as one forth, hence imparing the ability of the clot to withstand blood flow. This indicates higher risk of clot embolization in patients with overproduction of RBCs, such as during polycythaemia.  



Additional Information: ISMCM

Open to: General Public
Admission: Free
Sponsor: Mathematics

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