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Speaker: Juan Carlos del Alamo Department of Mechanical and Aerospace Engineering University of California San Diego

Interdisciplinary Seminar on Mathematical and Computational Modeling

Monday, May 15, 2017
  12:10–1:10 p.m.

Location: Surge Building 268
  Parking Information

Category: Seminar


Title: Quantifying Intracardiac Flow in the Clinical Setting

Abstract: Recent advances in imaging techniques now allow physicians to obtain robust measurements of intracardiac flows in the clinical setting.  Flow patterns inside the normal left ventricle (LV) are characterized by the formation of diastolic vortices, generated during filling that eventually last until the aortic valve is opened. In the failing LV, progressive adverse remodeling leads to abnormal vortex patterns that may vary the pumping efficiency. This talk will summarize recent clinical research about the contribution of intraventricular flow to LV function via three mechanisms 1) In diastole: by facilitating fluid transport and constraining the inflow to minimize pressure loss. 2) In systole: although currently being debated, by efficiently transferring kinetic energy from diastole to ejection. 3) In transport and mixing: by minimizing the number of cardiac cycles that blood stays in ventricular transit. We will illustrate how intraventricular flow quantification can be used to characterize and optimize the impact of clinical interventions and device implantation on intraventricular flow. Finally, we will provide an example of a prospective clinical study in which clinical analysis of intraventricular flow has been used predict intracardiac thrombus formation with the aim of guiding the prescription of anticoagulant therapy.

Bio. Prof. del Alamo received a B.S., M.S. and Ph. D. in Aerospace Engineering at the Polytechnic University in Madrid. He was a Fulbright postdoctoral fellow at Harvard University and UC Sand Diego, where he received training in experimental cell mechanics and cardiovascular flows. Prof. del Alamo’s lab at UCSD focuses on biological fluid mechanics, cellular locomotion and non-invasive characterization of cardiac flows. This research has been recognized with a US Geological Survey Director’s Award (2010), the NSF CAREER Award (2011), the Hellman Family Fellowship (2012), and the William Parmley Award from American College of Cardiology (2015).

Additional Information: ISMCM

Open to: General Public
Admission: Free
Sponsor: Mathematics

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