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Speaker: Sakhrat Khizroev, Florida International University

Interdisciplinary Seminar on Mathematical and Computational Modeling

Monday, June 5, 2017
  12:10–1:10 p.m.

Location: Surge Building 268
  Parking Information

Category: Seminar


Title: Applications of Magnetoelectric Nanoparticles in Cancer Research

Abstract: In regard to cancer therapy, magnetoelectric nanoparticles (MENs) have proven to be in a class of its own when compared to any other nanoparticle type. Like conventional magnetic nanoparticles, they can be used for externally controlled drug delivery via application of a magnetic field gradient and image-guided delivery. However unlike conventional nanoparticles, due to the presence of a non-zero magnetoelectric effect, MENs provide a unique mix of important properties to address key challenges in modern cancer therapy: (i) a targeting mechanism driven by a physical force rather than antibody matching, (ii) a high-specificity delivery to enhance the cellular uptake of therapeutic drugs across the cancer cell membranes only, while sparing normal cells, (iii) an externally controlled mechanism to release drugs on demand, and (iv) a capability for image guided precision medicine. These properties separate MENs-based targeted delivery from traditional biotechnology approaches and lay a foundation for the complementary approach of technobiology. The biotechnology approach stems from the underlying biology and exploits bioinformatics to find the right therapy. In contrast, the technobiology approach is geared towards using the physics of molecular-level interactions between cells and nanoparticles to treat cancer at the most fundamental level and thus can be extended to all the cancers. This presentation gives an overview of the MENs-based underlying physics of potential cancer therapy.

Bio: Professor Sakhrat Khizroev holds a joint appointment at the College of Engineering and the College of Medicine of Florida International University. His research focus is at the intersection of nanotechnology and medicine. Prior to returning to FIU in 2011 to lead the university-wide nanomedicine research, Khizroev was a tenured Professor of Electrical Engineering at the University of California, Riverside. Prior to joining academia, he spent four years with Seagate Research and one year with IBM Almaden Research Center. In the past, as an electrical engineer, he is most known for leading groundbreaking experiments which resulted in the multi-billion-dollar data storage industry’s shift towards perpendicular magnetic recording – the core modern technology. Fellow of National Academy of Inventors, he holds over 32 issued US patents in the field of nanomagnetic and spintronic devices. He received B.S./M.S. degrees in Physics from Moscow Institute of Physics and Technology in 1992/1994 and a PhD degree in Electrical and Computer Engineering from Carnegie Mellon University in 1999.

Additional Information: ISMCM

Open to: General Public
Admission: Free
Sponsor: Mathematics

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