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CEPCEB Seminar Dr. Xiaofeng Cao

Friday, June 16, 2017
  12:10–1 p.m.


Location: Genomics Building
  Parking Information

Category: Seminar

Description:

Dear Faculty, Postdocs, Students, and Friends:

You are cordially invited to a seminar presented by


 




Xiaofeng Cao


 


 Institute of Genetics and Developmental Biology Chinese Academy of Sciences


 


Title:


“Molecular mechanisms of histone demethylases in genome-wide targeting in Arabidopsis”



DATE: Friday, June 16, 2017


 LOCATION: Genomics Auditorium, RM 1102A


Time:12:10pm


 


 


Host: Xuemei Chen & Natasha Raikhel


 


Abstract:


Transcription activity of chromatin is regulated by covalent modifications on nucleosomes and DNA. Recent efforts have identified a lot of chromatin modifiers, which play important roles in various aspects of biological processes. These chromatin modifiers normally bind a subset of specific genomic loci. Discovering the mechanisms of recruiting these modifiers is essential for understanding the biological function of them. We previously identified Arabidopsis JMJ14 and JMJ12/REF6 as H3K4 and H3K27-specific histone demethylases. Further study shows both of them bind to their target genes in DNA sequence specific ways, but use distinct mechanisms. The C-terminal FYR domain of JMJ14 interacts with a pair of NAC domain containing transcription factors, which bring JMJ14 to their common target genes; whereas REF6 recognizes its target loci by direct recognizing specific DNA sequence through its tandem C2H2-Zinc finger domains. In this talk, I will illustrate how DNA sequence and other chromatin features fine-tune REF6 genome-wide targeting in Arabidopsis.


 



Open to: General Public
Admission: Free
Sponsor: Institute for Integrative Genome Biology

Contact Information:
Institute for Integrative Genome Biology
(951) 827-7177
genomics@ucr.edu