Virus-Cell Interactions in the Insect Midgut: Transcriptome Profiling and Envelope Protein Trafficking
The midgut is the first tissue encountered during insect infection by many viruses. The virus must enter and navigate through midgut cells and bud into the hemocoel to achieve successful systemic infection. To better understand the complex interactions between virus and host, we have used transcriptomic approaches to examine both viral and host transcription profiles in the midgut and in cultured insect cells infected by a baculovirus (Autographa californica multiple nucleopolyhedrovirus). The results reveal a tissue-specific viral gene expression program (and apparent manipulation of host gene expression), that facilitates more efficient viral movement through the midgut. Also, to better understand how many viruses navigate through midgut and other cells, we are also examining the trafficking of viral envelope proteins in insect cells using targeted RNAi screens of host cell proteins and pathways involved in envelope protein trafficking.
Monday, February 3 at 4:00pm to 4:50pm
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